Journal
ANNUAL REVIEW OF MEDICINE
Volume 61, Issue -, Pages 317-328Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.med.080608.100623
Keywords
liver cancer; genomics; personalized medicine; targeted therapy
Categories
Funding
- Bayer HealthCare Pharmaceuticals
- Bristol-Meyers-Squibb
- Novartis
- Sheila Sherlock (European Association for the Study of the Liver) fellowship
- Programa de Estancias de Movilidad Postdoctoral en el Extranjero incluidas las ayudas MICINN/Fulbright [EX 20080632]
- Instituto de Salud Carlos III [PI 05/645]
- BBVA Foundation
- National Institute of Health-NIDDK [1R01DK076986-01]
- National Institute of Health (Spain) [SAF-2007-61898]
- Samuel Waxman Cancer Research Foundation
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK076986] Funding Source: NIH RePORTER
- ICREA Funding Source: Custom
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The genomic era is changing the understanding of cancer, although translation of the vast amount of data available into decision-making algorithms is far from reality. Molecular profiling of hepatocellular carcinoma (HCC), the most common cause of death among cirrhotic patients and a fast-growing malignancy in Western countries, is enabling the advancement of novel approaches to disease diagnosis and management. Most HCCs arise on a cirrhotic liver, and predictably, an accurate genomic characterization will allow the identification of procarcinogenic signals amenable to selective targeting by chemopreventive strategies. Molecular diagnosis is currently feasible for small tumors, but it has not yet been formalized by scientific guidelines. Molecular treatment is a reality: Sorafenib confers unprecedented survival benefits in patients at advanced stages. Genomic information from tumor and nontumoral tissue will aid prognosis prediction and facilitate the identification of oncogene addiction loops, providing the opportunity for more personalized medicine.
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