4.5 Review Book Chapter

Emerging Molecular Targets for the Treatment of Nonalcoholic Fatty Liver Disease

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

MicroRNA expression pattern in different stages of nonalcoholic fatty liver disease

X. Jin et al.

DIGESTIVE AND LIVER DISEASE (2009)

Review Biochemistry & Molecular Biology

Targeting the AMPK pathway for the treatment of Type 2 diabetes

Benoit Viollet et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2009)

Article Gastroenterology & Hepatology

A Novel Pregnane X Receptor and S14-Mediated Lipogenic Pathway in Human Hepatocyte

Amelie Moreau et al.

HEPATOLOGY (2009)

Article Pharmacology & Pharmacy

Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet

Bo Kong et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Review Biotechnology & Applied Microbiology

Regulating the regulators: mechanisms controlling the maturation of microRNAs

Xavier C. Ding et al.

TRENDS IN BIOTECHNOLOGY (2009)

Review Pharmacology & Pharmacy

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: Crosstalk and consequences

Jean-Marc Pascussi et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2008)

Article Cell Biology

The let-7 microRNA reduces tumor growth in mouse models of lung cancer

Aurora Esquela-Kerscher et al.

CELL CYCLE (2008)

Review Medicine, Research & Experimental

MicroRNAs: role in cardiovascular biology and disease

Chunxiang Zhang

CLINICAL SCIENCE (2008)

Article Endocrinology & Metabolism

Exenatide prevents fat-induced insulin resistance and raises adiponectin expression and plasma levels

L. Li et al.

DIABETES OBESITY & METABOLISM (2008)

Editorial Material Pharmacology & Pharmacy

Selective thyromimetics for atherosclerosis and dyslipidaemia: another old target making progress

Keith Suckling

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2008)

Article Biochemistry & Molecular Biology

Thyroid hormone (T3) and TRβ agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats

Andrea Perra et al.

FASEB JOURNAL (2008)

Article Gastroenterology & Hepatology

Nonalcoholic Steatohepatitis Is Associated with Altered Hepatic MicroRNA Expression

Onpan Cheung et al.

HEPATOLOGY (2008)

Article Gastroenterology & Hepatology

Farnesoid X Receptor Antagonizes Nuclear Factor κB in Hepatic Inflammatory Response

Yan-Dong Wang et al.

HEPATOLOGY (2008)

Article Biochemistry & Molecular Biology

Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle

Eric B. Taylor et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Widespread changes in protein synthesis induced by microRNAs

Matthias Selbach et al.

NATURE (2008)

Article Multidisciplinary Sciences

LNA-mediated microRNA silencing in non-human primates

Joacim Elmen et al.

NATURE (2008)

Review Biotechnology & Applied Microbiology

Targeting bile-acid signalling for metabolic diseases

Charles Thomas et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Article Endocrinology & Metabolism

Effects of thyroid hormone analogs on lipid metabolism and thermogenesis

Miriam O. Ribeiro

THYROID (2008)

Article Multidisciplinary Sciences

The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans

Anders Berkenstam et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

miRBase: tools for microRNA genomics

Sam Griffiths-Jones et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Endocrinology & Metabolism

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet

Paula L. McClean et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

Article Multidisciplinary Sciences

Interferon modulation of cellular microRNAs as an antiviral mechanism

Irene M. Pedersen et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase

Qu Fan Collins et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Multidisciplinary Sciences

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Sibylle Jaeger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Gastroenterology & Hepatology

Biology of incretins: GLP-1 and GIP

Laurie L. Baggio et al.

GASTROENTEROLOGY (2007)

Article Biochemistry & Molecular Biology

Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver

Kouichi Nakamura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Medicine, Research & Experimental

Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure

Tanya Hansotia et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Biochemistry & Molecular Biology

CAR and PXR: The xenobiotic-sensing receptors

Yoav E. Timsit et al.

STEROIDS (2007)

Article Endocrinology & Metabolism

Pancreatic and extrapancreatic effects of gastric inhibitory polypeptide

Yuichiro Yamada et al.

DIABETES (2006)

Article Biochemistry & Molecular Biology

Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase

Marianne Suter et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Gastroenterology & Hepatology

Incretin mimetics as a novel therapeutic option for hepatic steatosis

Maarten E. Tushuizen et al.

LIVER INTERNATIONAL (2006)

Article Gastroenterology & Hepatology

Long-term follow-up of patients with NAFLD and elevated liver enzymes

Mattias Ekstedt et al.

HEPATOLOGY (2006)

Article Gastroenterology & Hepatology

Pregnane X receptor activators inhibit human hepatic stellate cell transdifferentiation in vitro

Emma L. Haughton et al.

GASTROENTEROLOGY (2006)

Article Biochemistry & Molecular Biology

Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice

T Arsov et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Medicine, Research & Experimental

Farnesoid X receptor is essential for normal glucose homeostasis

K Ma et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Multidisciplinary Sciences

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

T Inagaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Silencing of microRNAs in vivo with 'antagomirs'

J Krützfeldt et al.

NATURE (2005)

Article Multidisciplinary Sciences

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

SH Koo et al.

NATURE (2005)

Article Multidisciplinary Sciences

Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA

CL Jopling et al.

SCIENCE (2005)

Article Endocrinology & Metabolism

Long-term AICAR administration and exercise prevents diabetes in ZDF rats

R Pold et al.

DIABETES (2005)

Article Endocrinology & Metabolism

Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population

LS Szczepaniak et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)

Article Pharmacology & Pharmacy

Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1 alpha

RS Savkur et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Endocrinology & Metabolism

β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

RP Robertson et al.

DIABETES (2004)

Article Biochemistry & Molecular Biology

Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

S Kodama et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets

A Zhao et al.

DNA AND CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Adiponectin-mediated modulation of hypertrophic signals in the heart

R Shibata et al.

NATURE MEDICINE (2004)

Article Public, Environmental & Occupational Health

Dietary fat and the risk of clinical type 2 diabetes - The European Prospective Investigation of Cancer-Norfolk study

AH Harding et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2004)

Article Medicine, Research & Experimental

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

Y Horie et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Medicine, Research & Experimental

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

M Watanabe et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Gastroenterology & Hepatology

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression

T Claudel et al.

GASTROENTEROLOGY (2003)

Article Biochemistry & Molecular Biology

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

M Downes et al.

MOLECULAR CELL (2003)