Journal
ANNUAL REVIEW OF MEDICINE
Volume 60, Issue -, Pages 471-484Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.med.60.041807.123549
Keywords
human immunodeficiency virus; T lymphocyte; Th17 cells; cytokines; PD-1
Categories
Funding
- Intramural NIH HHS [Z99 AI999999] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI005021, ZIAAI005034, ZIAAI005066, ZIAAI005015, ZIAAI005014, ZIAAI005033] Funding Source: NIH RePORTER
Ask authors/readers for more resources
There is an intense interplay between HIV and the immune system, and the literature is replete with studies describing various immunological phenomena associated with HIV infection. Many of these phenomena seem too broad in scope to be attributable either to HIV-infected cells or to the HIV-specific immune response. Recently, a more fundamental understanding of how HIV affects various T cells and T cell compartments has emerged. This review covers the role of immune activation in HIV immunopathogenesis, how that activation could be mediated directly by HIV replicating within and damaging the gut mucosal barrier, how HIV affects multiple T cells functions and phenotypes, and how chronic HIV replication induces immune modulatory pathways to negatively regulate certain functions in HIV-specific T cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available