Journal
ANNUAL REVIEW OF MEDICINE
Volume 60, Issue -, Pages 139-151Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.med.60.042307.110714
Keywords
prostate-specific antigen (PSA); blood test; prostate biopsy; radical prostatectomy
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The development of biomarkers for prostate cancer screening, detection, and prognostication has revolutionized the management of this disease. Prostate-specific antigen (PSA) is a useful, though not specific, biomarker for detecting prostate cancer. We review the literature on prostate cancer biomarkers, including serum markers (PAP, tPSA, fPSA, proPSA, PSAD, PSAV, PSADT, EPCA, and EPCA-2), tissue markets (AMACR, methylated GSTP1, and the TMPRSS2-ETS gene rearrangement), and a urine marker (DD3PCA3/UPM-3). Future research should focus on validation of already existing biomarkers and the discovery of new markers to identify men with aggressive prostate cancer.
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