Journal
TETRAHEDRON
Volume 61, Issue 48, Pages 11418-11426Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.08.064
Keywords
propargylamines; chiral primary amines; three-component
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A general preparation of functionalized primary chiral amines and amides from propargylamines has been developed. The chirality is established by an enantioselective three-component reaction of an aldehyde, a terminal alkyne and a secondary amine in the presence of copper(I) bromide/Quinap as the catalytic system leading to chiral propargylamines in high yields and enantioselectivities. Functionalization and reduction leads to various primary amines and amides. (c) 2005 Published by Elsevier Ltd.
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