Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 140, Issue 2, Pages 133-145Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2005.07.004
Keywords
orbitofrontal cortex; schizophrenia; aggression; neuropsychological function
Categories
Funding
- NIMH NIH HHS [R01 MH064783, MH33127, P50 MH033127, R10 MH53550] Funding Source: Medline
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The relationship between orbitofirontal cortex (OFC) volumes and functional domains in treatment-resistant patients with schizophrenia or schizoaffective disorder is poorly understood. OFC dysfunction is implicated in several of the behaviors that are abnormal in schizophrenia. However, little is known about the relationship between these behaviors and OFC volumes. Forty-nine patients received magnetic resonance imaging scanning as part of a double-blind treatment study in which psychiatric symptomatology, neuropsychological function, and aggression were measured. OFC volumes were manually traced on anatomical images. Psychiatric symptomatology was measured with the Positive and Negative Syndrome Scale 'PANSS'. Aggression was measured with the Over, Aggression Scale OAS, and with the PANSS, Neuropsychological function was assessed using a comprehensive test battery. Larger right OFC volumes were associated with poorer neuropsychological function. Larger left OFC gray matter volumes and larger OFC white matter volumes bilaterally were associated with greater levels of aggression. These findings are discussed in the context of potential iatrogenic effects. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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