Journal
JOURNAL OF NEUROSCIENCE
Volume 25, Issue 48, Pages 11107-11116Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1678-05.2005
Keywords
NMDA receptors; NR2B; anterior cingulate cortex; inflammation; pain; hyperalgesia
Categories
Funding
- NINDS NIH HHS [R01 NS042722, NS42722] Funding Source: Medline
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Transgenic overexpression of NMDA NR2B receptors in forebrain regions increased behavioral responses to persistent inflammatory pain. However, it is not known whether inflammation leads to the upregulation of NR2B receptors in these regions. Here, we show that peripheral inflammation increased the expression of NMDA NR2B receptors and NR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC). In freely moving mice, the increase in NR2B receptors after inflammation contributed to enhanced NMDA receptor-mediated responses in the ACC. Inhibition of NR2B receptors in the ACC selectively reduced behavioral sensitization related to inflammation. Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation.
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