Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 32
Volume 32, Issue -, Pages 189-225Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-032713-120136
Keywords
adaptive immunity; adoptive immunotherapy; gene transfer; chimeric antigen receptor
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Funding
- NATIONAL CANCER INSTITUTE [K08CA166039, R01CA120409] Funding Source: NIH RePORTER
- NCI NIH HHS [K08 CA166039, R01 CA120409] Funding Source: Medline
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Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy. The primary challenge to the field is to identify tumor-specific targets to avoid off-tumor, on-target toxicity. Given recent advances in efficacy in numerous pilot trials, the next steps in clinical development will require multicenter trials to establish adoptive immunotherapy as a mainstream technology.
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