Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30
Volume 30, Issue -, Pages 531-564Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.immunol.25.022106.141623
Keywords
Foxp3; immune homeostasis; tolerance; autoimmunity
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [K99 AI089935, R37 AI034206] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI034206, K99AI089935] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The immune system has evolved to mount an effective defense against pathogens and to minimize deleterious immune-mediated inflammation caused by commensal microorganisms, immune responses against self and environmental antigens, and metabolic inflammatory disorders. Regulatory T (Treg) cell-mediated suppression serves as a vital mechanism of negative regulation of immune-mediated inflammation and features prominently in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation. The discovery that Foxp3 is the transcription factor that specifies the Treg cell lineage facilitated recent progress in understanding the biology of regulatory T cells. In this review, we discuss cellular and molecular mechanisms in the differentiation and function of these cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available