Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30
Volume 30, Issue -, Pages 295-312Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-020711-075013
Keywords
noncoding RNA; immune response; autoimmunity; infection
Categories
Funding
- NATIONAL CANCER INSTITUTE [K08CA133521] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R00HL102228] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI079243] Funding Source: NIH RePORTER
- NCI NIH HHS [K08 CA133521, 5K08-CA133251] Funding Source: Medline
- NHLBI NIH HHS [4R00HL102228-03] Funding Source: Medline
- NIAID NIH HHS [1R01AI079243-01] Funding Source: Medline
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The mammalian inflammatory response is a rapid and complex physiological reaction to noxious stimuli including microbial pathogens. Although inflammation plays a valuable role in combating infection, its dysregulation often occurs in people and can cause a variety of pathologies, ranging from chronic inflammation, to autoimmunity, to cancer. In recent years, our understanding of both the cellular and molecular networks that regulate inflammation has improved dramatically. Although much of the focus has been on the study of protein regulators of inflammation, recent evidence also points to a critical role for a specific class of noncoding RNAs, called microRNAs ( miRNAs), in managing certain features of the inflammatory process. In this review, we discuss recent advances in our understanding of miRNAs and their connection to inflammatory responses. Additionally, we consider the link between perturbations in miRNA levels and the onset of human inflammatory diseases.
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