Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30
Volume 30, Issue -, Pages 759-795Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-020711-074937
Keywords
intestinal microbiota; Th17 cells; Treg cells; innate lymphoid cells; segmented filamentous bacteria; Clostridium
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01AI080885, R01 AI080885] Funding Source: Medline
- NIAMS NIH HHS [RC2 AR058986] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI080885] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [RC2AR058986] Funding Source: NIH RePORTER
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The mammalian alimentary tract harbors hundreds of species of commensal microorganisms (microbiota) that intimately interact with the host and provide it with genetic, metabolic, and immunological attributes. Recent reports have indicated that the microbiota composition and its collective genomes (microbiome) are major factors in predetermining the type and robustness of mucosal immune responses. In this review, we discuss the recent advances in our understanding of host-microbiota interactions and their effect on the health and disease susceptibility of the host.
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