Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30
Volume 30, Issue -, Pages 491-529Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-031210-101352
Keywords
C-type lectins; innate immunity; endocytosis; pattern recognition; myeloid cells
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Funding
- Cancer Research UK Funding Source: Medline
- European Research Council [260414] Funding Source: Medline
- Cancer Research UK [15689] Funding Source: researchfish
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Myeloid cells are key drivers of physiological responses to pathogen invasion or tissue damage. Members of the C-type lectin receptor (CLR) family stand out among the specialized receptors utilized by myeloid cells to orchestrate these responses. CLR ligands include carbohydrate, protein, and lipid components of both pathogens and self, which variably trigger endocytic, phagocytic, proinflammatory, or anti-inflammatory reactions. These varied outcomes rely on a versatile system for CLR signaling that includes tyrosine-based motifs that recruit kinases, phosphatases, or endocytic adaptors as well as nontyrosine-based signals that modulate the activation of other pathways or couple to the uptake machinery. Here, we review the signaling properties of myeloid CLRs and how they impact the role of myeloid cells in innate and adaptive immunity.
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