Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29
Volume 29, Issue -, Pages 1-21Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-030409-101229
Keywords
pattern-recognition receptor; phagocytosis; inflammation; oxidative and nonoxidative microbial killing; Th17
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Funding
- Wellcome Trust [086558] Funding Source: Medline
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Fungal diseases have emerged as significant causes of morbidity and mortality, particularly in immune-compromised individuals, prompting greater interest in understanding the mechanisms of host resistance to these pathogens. Consequently, the past few decades have seen a tremendous increase in our knowledge of the innate and adaptive components underlying the protective (and nonprotective) mechanisms of antifungal immunity. What has emerged from these studies is that phagocytic cells are essential for protection and that defects in these cells compromise the host's ability to resist fungal infection. This review covers the functions of phagocytes in innate antifungal immunity, along with selected examples of the strategies that are used by fungal pathogens to subvert these defenses.
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