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SAP couples Fyn to SLAM immune receptors
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SAP is required for generating long-term humoral immunity
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Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts
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Mice deficient in the X-linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus-68 and hypo-gammaglobulinemia
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The dual-function CD150 receptor subfamily: the viral attraction
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Mutations of the X-linked lymphoproliferative disease gene SH2D1A mimicking common variable immunodeficiency
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The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon γ production
D Howie et al.
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Activation-dependent T cell expression of the X-linked lymphoproliferative disease gene product SLAM-associated protein and its assessment for patient detection
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Side-chain dynamics of the SAP SH2 domain correlate with a binding hot spot and a region with conformational plasticity
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CS1, a novel member of the CD2 family, is homophilic and regulates NK cell function
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2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: Properties required for 2B4 lytic function
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The X-linked lymphoproliferative disease gene product SAP is expressed in activated T and NK cells
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Early expression of triggering receptors and regulatory role of 2134 in human natural killer cell precursors undergoing in vitro differentiation
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The activatory receptor 2B4 is expressed in vivo by human CD8+ effector αβ T cells
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2B4 (CD244)-mediated activation of cytotoxicity and IFN-γ release in human NK cells involves distinct pathways
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Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells
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X-Linked lymphoproliferative disease: three atypical cases
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CD84 functions as a homophilic adhesion molecule and enhances IFN-γ secretion:: Adhesion is mediated by Ig-like domain 1
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Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines
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Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome
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CD2F-10: a new member of the CD2 subset of the immunoglobulin superfamily
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Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset
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Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1β
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GNTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr-virus-infected B cells in X-linked lymphoproliferative disease
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CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells
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IMMUNOGENETICS (2001)
Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family
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Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP
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Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP
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Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2
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Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9
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CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A
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Hemophagocytic lymphohistiocytosis due to germline mutations in SH2D1A, the X-linked lymphoproliferative disease gene
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The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
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Molecular cloning of CS1, a navel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily
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Potential pathways for regulation of NK and T cell responses:: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4
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Ly108: a new member of the mouse CD2 family of cell surface proteins
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Cutting edge: Defective NK cell activation in X-linked lymphoproliferative disease
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Cutting edge: Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome
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T cell immune reconstitution after allogeneic bone marrow transplantation in bare lymphocyte syndrome
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SLAM (CDw150) is a cellular receptor for measles virus
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2B4-mediated activation of human natural killer cells
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