Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28
Volume 28, Issue -, Pages 157-183Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-030409-101305
Keywords
C reactive protein; serum amyloid P component; ficolins; collectins; complement; phagocytes
Categories
Funding
- Telethon [GGP05095] Funding Source: Medline
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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The innate immune system consists of a cellular and a humoral arm. Pentraxins (e.g., the short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the humoral arm of innate immunity which also includes complement components, collectins, and ficolins. In response to microorganisms and tissue damage, neutrophils, macrophages, and dendritic cells are major sources of fluid-phase pattern-recognition molecules (PRMs) belonging to different molecular classes. Humoral PRMs in turn interact with and regulate cellular effectors. Effector mechanisms of the Immoral innate immune system include activation and regulation of the complement cascade; agglutination and neutralization; facilitation of recognition via cellular receptors (opsonization); and regulation of inflammation. Thus, the humoral arm of innate immunity is an integrated system consisting of different molecules and sharing functional outputs with antibodies.
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