Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28
Volume 28, Issue -, Pages 131-155Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-030409-101250
Keywords
apoptosis; complement; neutrophil granules; pattern recognition
Categories
Funding
- Medical Research Council [G0600698B] Funding Source: researchfish
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI070489, R01AI051436] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI051436-07, U 19 AI070489] Funding Source: Medline
Ask authors/readers for more resources
Complement is an innate immune system that is a first line of defense against pathogens and facilitates elimination of apoptotic and injured cells. During complement activation, the complement convertases are assembled on target surfaces and initiate their proteolytic activities, a process that marks targets for phagocytosis and/or lysis. The complement alternative activation pathway has been implicated in a number of autoimmune conditions including arthritis and age-related macular degeneration. Properdin, a plasma component that is also released by activated neutrophils, is critical in the stabilization of alternative pathway convertases. Recently, it has been shown that properdin is also a pattern-recognition molecule that binds to certain microbial surfaces, apoptotic cells, and necrotic cells. Once bound to a surface, properdin can direct convertase formation and target uptake. New studies are now focusing on a role for properdin in inflammatory and autoimmune diseases. This review examines the new properdin findings and their implications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available