Journal
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28
Volume 28, Issue -, Pages 535-571Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-030409-101221
Keywords
microarray; blood; biomarkers; lupus; juvenile arthritis
Categories
Funding
- NCI NIH HHS [R01 CA078846, R01 CA078846-04, R01 CA078846-01A1, R01 CA078846-10, R01 CA078846-07, R01 CA078846-09, R01 CA078846-06, R01 CA078846-08, R01 CA078846-05, R01 CA078846-03, R01-CA078846, R01 CA078846-02] Funding Source: Medline
- NIAID NIH HHS [U19 AI057234-010004, U19 AI057234-05S1, U19 AI057234, U19 AI057234-06S2, U19-AI082715-01, U19 AI057234-01, U19 AI057234-06S17749, U19 AI057234-03, U19 AI057234-010005, U01AI082110, U19 AI057234-05S19003, U19 AI057234-06S25842, U19 AI082715-017351, U19 AI057234-06S3, U19 AI057234-010006, U19 AI057234-06S37751, U19 AI057234-04, U19 AI057234-05, U19 AI057234-068136, U19 AI082715, U19 AI057234-02, U19 AI082715-017348, U01 AI082110, U19 AI057234-05S10012, U19 AI057234-068130, U19 AI057234-06, U19 AI057234-05S10013, U19 AI082715-01, U19 AI057234-06S28136, U01 AI082110-01, U19 AI057234-06S1, U19 AI057234-06S28130] Funding Source: Medline
- NIAMS NIH HHS [P50 AR054083-030001, R01 AR050770-03, P50 AR055503, P50 AR054083-010002, P50 AR055503-020004, P50 AR054083-040001, P50 AR055503-010004, P50 AR054083-030002, P50 AR054083-040002, R01 AR050770-06, P50 AR054083-029001, P50 AR054083-02, P50 AR054083, R01 AR050770-01, R01 AR050770-04, R01 AR050770-05A1, P50 AR054083-020002, P50 AR054083-03, R01 AR050770, P50 AR054083-01, P50 AR054083-020001, P50 AR054083-019001, P50 AR054083-010001, P50 AR054083-04, R01 AR050770-02, P50 AR054083-04S1, P50 AR055503-030004] Funding Source: Medline
- PHS HHS [ARO55503-01CORT, U19-A1057234, ARO54083-01CORT] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA078846] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI082715, U01AI082110, U19AI057234] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P50AR055503, P50AR054083, R01AR050770] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The past decade has seen an explosion in the use of DNA-based microarrays. These techniques permit assessment of RNA abundance on a genome-wide scale. Medical applications emerged in the field of cancer, with studies of both solid tumors and hematological malignancies leading to the development of tests that are now used to personalize therapeutic options. Microarrays have also been used to analyze the blood transcriptome in a wide range of diseases. In human autoimmune diseases, these studies are showing potential for identifying therapeutic targets as well as biomarkers for diagnosis, assessment of disease activity, and response to treatment. More quantitative and sensitive high-throughput RNA profiling methods are starting to be available and will be necessary for transcriptome analyses to become routine tests in the clinical setting. We expect this to crystallize within the coming decade, as these methods become part of the personalized medicine armamentarium.
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