Journal
ANNUAL REVIEW OF IMMUNOLOGY
Volume 27, Issue -, Pages 551-589Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.immunol.021908.132723
Keywords
infection; Foxp3; dendritic cells; Treg
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Funding
- Division of Irtramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
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Each microenvironment requires a specific set of regulatory elements that ire finely and constantly tuned to maintain local homeostasis. Various populations of regulatory T cells contribute to the maintenance of this equilibrium and establishment of controlled immune responses. In particular, regulatory T cells limit the magnitude of effector responses, which may result in failure to adequately control infection. However, regulatory T cells also hell) limit collateral tissue damage caused by vigorous antimicrobial immune responses against pathogenic microbes as well as commensals. In this review, we describe various situations in which the balance between regulatory T cells and effector immune functions influence the outcome of host-microorganism coexistence and discuss current hypotheses and points of polemic associated with the origin, target, and antigen specificity of both endogenous and induced regulatory T cells during these interactions.
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