Journal
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
Volume 19, Issue 6, Pages 1089-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2005.09.011
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Malignant pleural mesothelioma (MPM) is relatively unique among cancers, since the local and regional disease rather than the systemic disease usually contributes to death. Because of its multifocal distribution in the chest, MPM progresses locally by compressing the lung, heart, and major vessels, and causes death by cardiac tamponade and lung collapse physiology. The therapy for this aggressive local malignancy is currently inadequate. In most cases there is insufficient time for systemic disease to develop or contribute to mortality. The first order of therapy in MPM is currently, as it has been for decades, to control effectively the tumor's locoregional spread and then deal with controlling the distant disease.
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