Journal
ANNUAL REVIEW OF IMMUNOLOGY
Volume 26, Issue -, Pages 293-316Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.immunol.26.021607.090254
Keywords
chemotaxis; lymphatic vessel; postcapillary venule; lymph node
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The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a consequence of their localization within tissues and their specialized capacity for mobilization. The migration of a given DC subset is typified by a restricted capacity for recirculation, contrasting markedly with T cells. Routes of DC migration into lymph nodes differ notably for distinct DC subsets. Here, we compare the distinct migratory patterns of plasmacytoid DCs (pDCs), CD8 alpha(+) DCs, Langerhans cells, and conventional myeloid DCs and discuss how the highly regulated patterns of DC migration in vivo may affect their roles in immunity. Finally, to gain a more molecular appreciation of the specialized migratory properties of DCs, we review the signaling cascades that govern the process of DC migration.
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