Journal
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 15
Volume 15, Issue -, Pages 127-150Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genom-090413-025405
Keywords
epitranscriptome; RNA editing; ribonucleotide modifications; m(6)A
Categories
Funding
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG006798] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS076465] Funding Source: NIH RePORTER
- NHGRI NIH HHS [R01HG006798] Funding Source: Medline
- NINDS NIH HHS [R01NS076465] Funding Source: Medline
Ask authors/readers for more resources
Posttranscriptionally modified nucleosides in RNA play integral roles in the cellular control of biological information that is encoded in DNA. The modifications of RNA span all three phylogenetic domains (Archaea, Bacteria, and Eukarya) and are pervasive across RNA types, including messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and (less frequently) small nuclear RNA (snRNA) and microRNA (miRNA). Nucleotide modifications are also one of the most evolutionarily conserved properties of RNAs, and the sites of modification are under strong selective pressure. However, many of these modifications, as well as their prevalence and impact, have only recently been discovered. Here, we examine both labile and permanent modifications, from simple methylation to complex transcript alteration (RNA editing and intron retention); detail the models for their processing; and highlight remaining questions in the field of the epitranscriptome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available