Journal
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 13
Volume 13, Issue -, Pages 29-57Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genom-090711-163723
Keywords
ChIP-Seq; chromatin; pioneer factors; poised enhancers and promoters; transcriptional competence; location analysis
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIGMS NIH HHS [R01GM033977, R01 GM033977] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM033977] Funding Source: NIH RePORTER
Ask authors/readers for more resources
There has been a recent surge in the use of genome-wide methodologies to identify and annotate the transcriptional regulatory elements in the human genome. Here we review some of these methodologies and the conceptual insights about transcription regulation that have been gained from the use of genome-wide studies. It has become clear that the binding of transcription factors is itself a highly regulated process, and binding does not always appear to have functional consequences. Numerous properties have now been associated with regulatory elements that may be useful in their identification. Several aspects of enhancer function have been shown to be more widespread than was previously appreciated, including the highly combinatorial nature of transcription factor binding, the postinitiation regulation of many target genes, and the binding of enhancers at early stages to maintain their competence during development. Going forward, the integration of multiple genome-wide data sets should become a standard approach to elucidate higher-order regulatory interactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available