Journal
ZEITSCHRIFT FUR KARDIOLOGIE
Volume 94, Issue 12, Pages 817-823Publisher
DR DIETRICH STEINKOPFF VERLAG
DOI: 10.1007/s00392-005-0293-3
Keywords
intoxication; child; oleander; cardiac glycosides; digoxin-specific Fab antibody; fragments
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A 7-year-old girl presented six hours after ingestion of a yellow oleander seed (Thevetia peruviana) with severe emesis, change in colour vision and complete heart block. Initial treatment with phenytoin and isoprenalin infusion led to intermittent supraventricular and ventricular tachycardia. The patient was then treated with two intravenous doses of 190 mg of digoxin-specific Fab antibody fragments (Digibind(R)). Subsequently the patient's rhythm reverted to sinus rhythm and the symptoms resolved within 2 hours. Conclusion administration of digoxin-specific Fab antibody fragments in an otherwise healthy child after oleander intoxication is safe and without adverse reactions.
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