Journal
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 12
Volume 12, Issue -, Pages 301-325Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genom-082410-101440
Keywords
alpha-synuclein; LRRK2; parkin; PINK1; DJ-1; PARIS
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS051764, R01NS048206, P50NS038377] Funding Source: NIH RePORTER
- NINDS NIH HHS [R01 NS048206, P50 NS038377, NS051764, R01 NS051764, NS048206] Funding Source: Medline
- PHS HHS [MS38377] Funding Source: Medline
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Genetic studies have provided valuable insight into the pathological mechanisms underlying Parkinson's disease (PD). The elucidation of genetic components to what was once largely considered a nongenetic disease has given rise to a multitude of cell and animal models enabling the dissection of molecular pathways involved in disease etiology. Here, we review advances obtained from models of dominant mutations in alpha-synuclein and LRRK2 as well as recessive PINK1, parkin and DJ-1 mutations. Recent genome-wide association studies have implicated genetic variability at two of these loci, alpha-synuclein and LRRK2, as significant risk factors for developing sporadic PD. This, coupled with the established role of mitochondrial impairment in both familial and sporadic PD, highlights the likelihood of common mechanisms fundamental to the etiology of both.
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