Journal
ANNUAL REVIEW OF GENETICS, VOL 48
Volume 48, Issue -, Pages 187-214Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120213-092304
Keywords
Spo11; DNA double-strand breaks; cell cycle; ATM; DNA replication
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NICHD NIH HHS [R01 HD053855, HD053855] Funding Source: Medline
- NIGMS NIH HHS [GM105421, R01 GM058673, R01 GM105421, GM058673] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD053855] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM058673, R01GM105421] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Recombination in meiosis is a fascinating case study for the coordination of chromosomal duplication, repair, and segregation with each other and with progression through a cell-division cycle. Meiotic recombination initiates with formation of developmentally programmed DNA double-strand breaks (DSBs) at many places across the genome. DSBs are important for successful meiosis but are also dangerous lesions that can mutate or kill, so cells ensure that DSBs are made only at the right times, places, and amounts. This review examines the complex web of pathways that accomplish this control. We explore how chromosome breakage is integrated with meiotic progression and how feedback mechanisms spatially pattern DSB formation and make it homeostatic, robust, and error correcting. Common regulatory themes recur in different organisms or in different contexts in the same organism. We review this evolutionary and mechanistic conservation but also highlight where control modules have diverged. The framework that emerges helps explain how meiotic chromosomes behave as a self-organizing system.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available