Journal
ANNUAL REVIEW OF GENETICS, VOL 48
Volume 48, Issue -, Pages 537-559Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120213-092340
Keywords
mRNA stability; ribonuclease; gene regulation; translation; sRNA
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM101962, R01GM035769] Funding Source: NIH RePORTER
- NIGMS NIH HHS [F32 GM101962, F32GM101962, R01 GM035769, R01GM035769] Funding Source: Medline
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mRNA degradation is an important mechanism for controlling gene expression in bacterial cells. This process involves the orderly action of a battery of cellular endonucleases and exonucleases, some universal and others present only in certain species. These ribonucleases function with the assistance of ancillary enzymes that covalently modify the 5' or 3' end of RNA or unwind base-paired regions. Triggered by initiating events at either the 5' terminus or an internal site, mRNA decay occurs at diverse rates that are transcript specific and governed by RNA sequence and structure, translating ribosomes, and bound sRNAs or proteins. In response to environmental cues, bacteria are able to orchestrate widespread changes in mRNA lifetimes by modulating the concentration or specific activity of cellular ribonucleases or by unmasking the mRNA-degrading activity of cellular toxins.
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