Journal
ANNUAL REVIEW OF GENETICS, VOL 48
Volume 48, Issue -, Pages 71-97Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-120213-092148
Keywords
Archaea; initiation of DNA replication; protein-DNA interactions; protein-protein interactions; regulation of DNA replication; protein structure
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DNA replication is essential for all life forms. Although the process is fundamentally conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic studies have demonstrated that the process and the proteins involved in archaeal DNA replication are more similar to those in eukaryal DNA replication than in bacterial DNA replication, but have some archaeal-specific features. The archaeal replication system, however, is not monolithic, and there are some differences in the replication process between different species. In this review, the current knowledge of the mechanisms governing DNA replication in Archaea is summarized. The general features of the replication process as well as some of the differences are discussed.
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