Journal
ANNUAL REVIEW OF GENETICS, VOL 46
Volume 46, Issue -, Pages 591-615Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-110711-155517
Keywords
transcriptomics; regulatory networks; systems biology; behavioral state; Apis mellifera
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Funding
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD006416] Funding Source: NIH RePORTER
- NIH HHS [1DP1OD006416] Funding Source: Medline
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Behavior is a complex phenotype that is plastic and evolutionarily labile. The advent of genomics has revolutionized the field of behavioral genetics by providing tools to quantify the dynamic nature of brain gene expression in relation to behavioral output. The honey bee Apis mellifera provides an excellent platform for investigating the relationship between brain gene expression and behavior given both the remarkable behavioral repertoire expressed by members of its intricate society and the degree to which behavior is influenced by heredity and the social environment. Here, we review a linked series of studies that assayed changes in honey bee brain transcriptomes associated with natural and experimentally induced changes in behavioral state. These experiments demonstrate that brain gene expression is closely linked with behavior, that changes in brain gene expression mediate changes in behavior, and that the association between specific genes and behavior exists over multiple timescales, from physiological to evolutionary.
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