Journal
ANNUAL REVIEW OF GENETICS, VOL 46
Volume 46, Issue -, Pages 443-453Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-110711-155419
Keywords
CENP-C; CENH3/CENP-A; pericentromere; satellite; transcription; chromosomal passenger complex
Categories
Funding
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [0922703] Funding Source: National Science Foundation
- NIGMS NIH HHS [F32GM095223] Funding Source: Medline
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Despite many challenges, great progress has been made in identifying kinetochore proteins and understanding their overall functions relative to spindles and centromeric DNA. In contrast, less is known about the specialized centromeric chromatin environment and how it may be involved in regulating the assembly of kinetochore proteins. Multiple independent lines of evidence have implicated transcription and the resulting RNA as an important part of this process. Here, we summarize recent literature demonstrating the roles of centromeric RNA in regulating kinetochore assembly and maintenance. We also review literature suggesting that the process of centromeric transcription may be as important as the resulting RNA and that such transcription may be involved in recruiting the centromeric histone variant CENH3.
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