Journal
NATURE MEDICINE
Volume 11, Issue 12, Pages 1295-1298Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1330
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Funding
- NIAID NIH HHS [AI38899] Funding Source: Medline
- NIDDK NIH HHS [R01 DK029961-19, R01DK64207] Funding Source: Medline
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We transplanted kidneys from alpha 1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GaIT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GaIT-KO pigs to humans.
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