Journal
ANNUAL REVIEW OF GENETICS, VOL 44
Volume 44, Issue -, Pages 393-417Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-genet-102209-163602
Keywords
RecQ; Werner syndrome; Bloom syndrome; Rothmund-Thomson syndrome; homologous recombination; DNA repair
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Funding
- NIGMS NIH HHS [GM088413, R01 GM050237, R01 GM067055, GM078840, R00 GM088413, K99 GM088413, R37 GM050237, F32 GM078840, GM50237] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R00GM088413, R01GM067055, R37GM050237, F32GM078840, K99GM088413, R01GM050237] Funding Source: NIH RePORTER
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The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double :Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well IS at specific genomic loci such as telomeres.
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