Journal
ANNUAL REVIEW OF GENETICS
Volume 42, Issue -, Pages 143-163Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.genet.42.110807.091704
Keywords
Trim5 alpha; Trim28; Zap; Tetherin; APOBEC; intrinsic immunity
Categories
Funding
- National Cancer Institute [R37 CA 30488]
- NATIONAL CANCER INSTITUTE [R37CA030488] Funding Source: NIH RePORTER
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Retroviruses are highly successful intracellular parasites, anti as such they are found in nearly all branches of life. Some are relatively benign, but many are highly pathogenic anti can cause either acute or chronic diseases. Therefore, there is tremendous selective pressure on the host to prevent retroviral replication, and for this reason cells have evolved a variety of restriction factors that act to inhibit or block the viruses. This review is a survey of the best-characterized restriction factors capable of inhibiting retroviral replication anti aims to highlight the diversity of strategies used for this task.
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