Journal
NEUROBIOLOGY OF AGING
Volume 26, Issue -, Pages S65-S69Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2005.08.021
Keywords
insulin; Alzheimer; amyloid; diabetes; inflammation; obesity
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Funding
- NIAMS NIH HHS [NIAR01 AG-10880] Funding Source: Medline
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Insulin plays an important role in memory and other aspects of brain function. The insulin resistance syndrome. characterized by chronic peripheral insulin elevations, reduced insulin activity, and reduced brain insulin levels, is associated with age-related memory impairment and g Alzheimer's disease (AD). Our work has focused on specific mechanisms through which this association is forged, including the effects of peripheral hyperinsulinemia on memory, inflammation, and regulation of the beta-amyloid peptide that plays a key role in AD pathophysiology. Our data suggest that excessive insulin invokes synchronous increases in levels of A beta and inflammatory agents. effects that are exacerbated by age and obesity. This constellation of events may have deleterious effects on memory. Treatments focused on preventing or correcting insulin abnormalities may be of therapeutic benefit for adults with age-related memory impairment and AD. (c) 2005 Published by Elsevier Inc.
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