Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 33, Issue 12, Pages 1714-1718Publisher
SPRINGER
DOI: 10.1007/s10439-005-8774-0
Keywords
mechanotransduction; biomechanics; high throughput analyses; atherosclerosis; vascular biology
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The relationships between blood flow, mechanotransduction, and the localization of arterial lesions can now be advanced by the incorporation of new technologies and the refinement of existing methods in imaging modalities, computational modeling, fluid dynamics, and high throughput genomics and proteomics. When combined with traditional cell and molecular technologies, a powerful palette of investigative approaches is available to address shear stress biology of the endothelium at levels extending from nanoscale subcellular detailed mechanistic responses through to higher organizational levels of regional endothelial phenotypes and heterogeneous vascular beds.
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