Journal
ANNUAL REVIEW OF ECOLOGY, EVOLUTION, AND SYSTEMATICS, VOL 45
Volume 45, Issue -, Pages 179-201Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-ecolsys-120213-091846
Keywords
Fisher's geometric model; adaptive landscape; distribution of fitness effects; epistasis; pleiotropy; phenotypic complexity; robustness; drift load
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Funding
- European Research Council [310944] Funding Source: Medline
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The accumulation of data on the genomic bases of adaptation has triggered renewed interest in theoretical models of adaptation. Among these models, Fisher's geometric model (FGM) has received a lot of attention over the past two decades. FGM is based on a continuous multidimensional phenotypic landscape, but it is mostly used for the emerging properties of individual mutation effects. Despite its apparent simplicity and limited number of parameters, FGM integrates a full model of mutation and epistatic interactions that allows the study of both beneficial and deleterious mutations and, subsequently, the fate of evolving populations. In this review, I present the different properties of FGM and the qualitative and quantitative support they have received from experimental evolution data. I then discuss how to estimate the different parameters of the model and outline some future directions to connect FGM and the molecular determinants of adaptation.
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