Journal
CELLULAR SIGNALLING
Volume 17, Issue 12, Pages 1457-1465Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2005.05.020
Keywords
G protein-coupled receptor; export trafficking; ER-export motif; rab GTPase; glycosylation; signal transduction
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Funding
- NCRR NIH HHS [1P20RR018766] Funding Source: Medline
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G protein-coupled receptors (GPCRs) are a superfamily of cell-surface receptors that regulate a variety of cell functions by responding to a myriad of ligands. The magnitude of the response elicited by a ligand is dictated by the level of receptor available at the plasma membrane. GPCR expression levels at the cell surface are a balance of three highly regulated, dynamic intracellular trafficking processes, namely export, internalization and degradation. This review will cover recent advances in understanding the mechanism underlying GPCR export trafficking by focusing on specific motifs required for ER export and the role of the Ras-like Rab 1 GTPase and glycosylation in regulating ER-Golgi-cell-surface transport. The manifestation of diseases due to the disruption of GPCR export is also discussed. (c) 2005 Elsevier Inc. All rights reserved.
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