Journal
SEMINARS IN IMMUNOLOGY
Volume 17, Issue 6, Pages 400-410Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2005.09.002
Keywords
intravital microscopy; immunological synapse; total internal reflection fluorescence microscopy; T cell receptor; signalling
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T cell activation requires interactions of T cell antigen receptors (TCR) and peptides presented by major histocompatibility complex molecules (MHCp) in an adhesive junction between the T cell and antigen-presenting cell. Stable junctions with bull's eye supramolecular activation Clusters C (SMACs) have been defined as immunological synapses (IS). These structures maintain T cell-APC interaction and allow directed secretion. T cells can also be activated by asymmetric hemi-synapses (HS) that allow migration during signal integration. IS and HS operate in different stages of T cell priming. Optimal effector functions may also depend upon cyclical use of IS and HS. (c) 2005 Published by Elsevier Ltd.
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