Journal
GUT
Volume 54, Issue 12, Pages 1802-1809Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/gut.2005.068601
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In this article, we discuss the current understanding of how the intestinal mucosa may exert control over luminal bacteria, and how intestinal inflammation could ensue when this control is lost. We shall review research showing how Paneth cells, and evolutionarily conserved innate immune mechanisms, are emerging as key mediators of intestinal mucosal defence.
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