Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 124, Issue 6, Pages 910-917Publisher
OXFORD UNIV PRESS INC
DOI: 10.1309/W76QF806CE80CL2T
Keywords
von Willebrand factor; vWF; von Willebrand disease; von Willebrand disorder; vWD; laboratory assessment; ABO blood group; sex; age; normal reference ranges
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We reassessed the influence of ABO blood group, sex, and age on plasma levels of von Willebrand factor (vWF) antigen, vWF:ristocetin cofactor, vWF:collagen binding assay, and,factor VIII coagulant (FVIII:C). Data show, that levels of vWF and FVIII.-C increase with increasing age (P < . 001 for all parameters) and that the ABO blood group influences plasma levels such that O group levels are significantly less than. non-O group levels. There was no significant association with se,v and Rh status. The selection of normal ranges based on ABO blood groups may influence the clinical diagnosis of von Willebrand disease (vWD) but might not be clinically, relevant or help identify people at increased risk of bleeding. Differences in A BO-related ranges were more extensive at the high end of the ranges. This is of particular interest because high levels of vWF and FVIII are associated with thrombosis risk, and an ABO relationship also has been described. 0 group individuals may or may not be at greater risk for bleeding (they have lower levels of vWF and FVIII:C) and are more likely to be diagnosed with vWD. It also is possible that O group status may be protective for thrombosis.
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