Journal
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
Volume 34, Issue 6, Pages 1370-1376Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyi184
Keywords
epidemiological methods; misclassification; Monte Carlo method; sensitivity and specificity; sensitivity analysis
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Background Misclassification bias is present in most studies, yet uncertainty about its magnitude or direction is rarely quantified. Methods The authors present a method for probabilistic sensitivity analysis to quantify likely effects of misclassification of a dichotomous outcome, exposure or covariate. This method involves reconstructing the data that would have been observed had the misclassified variable been correctly classified, given the sensitivity and specificity of classification. The accompanying SAS macro implements the method and allows users to specify ranges of sensitivity and specificity of misclassification parameters to yield simulation intervals that incorporate both systematic and random error. Results The authors illustrate the method and the accompanying SAS macro code by applying it to a study of the relation between occupational resin exposure and lung-cancer deaths. The authors compare the results using this method with the conventional result, which accounts for random error only, and with the original sensitivity analysis results. Conclusion By accounting for plausible degrees of misclassification, investigators can present study results in a way that incorporates uncertainty about the bias due to misclassification, and so avoid misleadingly precise-looking results.
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