Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30
Volume 30, Issue -, Pages 79-109Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100913-013439
Keywords
pore-forming toxins; endocytic/secretory pathway; autophagy; caspase-11; Legionella; Salmonella
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R56 AI023538, R21 AI097728] Funding Source: Medline
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Pathogens use a vast number of strategies to alter host membrane dynamics. Targeting the host membrane machinery is important for the survival and pathogenesis of several extracellular, vacuolar, and cytosolic bacteria. Membrane manipulation promotes bacterial replication while suppressing host responses, allowing the bacterium to thrive in a hostile environment. This review provides a comprehensive summary of various strategies used by both extracellular and intracellular bacteria to hijack host membrane trafficking machinery. We start with mechanisms used by bacteria to alter the plasmamembrane, delve into the hijacking of various vesicle trafficking pathways, and conclude by summarizing bacterial adaptation to host immune responses. Understanding bacterial manipulation of host membrane trafficking provides insights into bacterial pathogenesis and uncovers the molecular mechanisms behind various processes within a eukaryotic cell.
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