Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 29
Volume 29, Issue -, Pages 213-239Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-101512-122343
Keywords
embryonic stem cells; reprogramming; epiblast; ESCC; induced pluripotent stem cells
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Funding
- NIGMS NIH HHS [R01 GM101180] Funding Source: Medline
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In the past decade, significant progress has been made in understanding both microRNA function and cellular pluripotency. Here we review the intersection of these two exciting fields. While microRNAs are not required for the establishment and maintenance of pluripotency in early development and cell culture, respectively, they are critically important in the regulation of the cell cycle structure of pluripotent stem cells as well as the silencing of the pluripotency program upon differentiation. Pluripotent cells, both in vivo and in vitro, dominantly express a single family of microRNAs, which can promote the reprogramming of a somatic cell back to a pluripotent state. Here, we review the known mechanisms by which these and other microRNAs regulate the different aspects of the pluripotent stem cell program in both mouse and human.
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