Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 29
Volume 29, Issue -, Pages 529-550Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-101512-122328
Keywords
atlastin; mitofusin; dynamin-related proteins; endomembrane
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Funding
- NIGMS NIH HHS [R01 GM101377] Funding Source: Medline
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1243792] Funding Source: National Science Foundation
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Shape changes and topological remodeling of membranes are essential for the identity of organelles and membrane trafficking. Although all cellular membranes have common features, membranes of different organelles create unique environments that support specialized biological functions. The endoplasmic reticulum (ER) is a prime example of this specialization, as its lipid bilayer forms an interconnected system of cisternae, vesicles, and tubules, providing a highly compartmentalized structure for a multitude of biochemical processes. A variety of peripheral and integral membrane proteins that facilitate membrane curvature generation, fission, and/or fusion have been identified over the past two decades. Among these, the dynamin-related proteins (DRPs) have emerged as key players. Here, we review recent advances in our functional and molecular understanding of fusion DRPs, exemplified by atlastin, an ER-resident DRP that controls ER structure, function, and signaling.
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