Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27
Volume 27, Issue -, Pages 681-696Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-092910-154226
Keywords
neuronal identity; transcriptional regulation; terminal selector; regulon
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NINDS NIH HHS [R01NS039996-05, R01NS050266-03] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050266, R01NS039996] Funding Source: NIH RePORTER
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The generation of individual neuron types in the nervous system is a multistep process whose endpoint is the expression of neuron type specific batteries of terminal differentiation genes that determine the functional properties of a neuron. This review focuses on the regulatory mechanisms that are involved in controlling the terminally differentiated state of a neuron. I review several case studies from invertebrate and vertebrate nervous systems that reveal that many terminal differentiation features of a neuron are coregulated via terminal selector transcription factors that initiate and maintain terminal differentiation programs.
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