Replicative Aging in Yeast: The Means to the End

Progress in aging research is nom, rapid, and surprisingly studies ill a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved between, yeast and multicellular eukaryotes is being tested. In this review, we provide a brief retrospective view oil the development of yeast as it model for aging and then turn to recent discoveries that have pushed aging research into novel directions and also linked aging in yeast to well-developed hypotheses in mammals. Although the question of what causes aging still cannot he answered definitively, that day may be he rapidly approaching.