Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
Volume 24, Issue -, Pages 29-54Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.23.090506.123509
Keywords
longevity; dietary restriction; SIR2; TOR; life span
Categories
Funding
- Hereditary Disease Foundation
- Ellison Medical Foundation
- AFAR
- NIH
- NATIONAL INSTITUTE ON AGING [R01AG025549] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Progress in aging research is nom, rapid, and surprisingly studies ill a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved between, yeast and multicellular eukaryotes is being tested. In this review, we provide a brief retrospective view oil the development of yeast as it model for aging and then turn to recent discoveries that have pushed aging research into novel directions and also linked aging in yeast to well-developed hypotheses in mammals. Although the question of what causes aging still cannot he answered definitively, that day may be he rapidly approaching.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available