Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 115, Issue 12, Pages 3378-3384Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI27196
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Platelets represent an important linkage between inflammation, thrombosis, and atherogenesis. Inflammation is characterized by interactions among platelets, leukocytes, and ECs. These interactions trigger autocrine and paracrine activation processes that lead to leukocyte recruitment into the vascular wall. Platelet-induced chronic inflammatory processes at the vascular wall result in development of atherosclerotic lesions and atherothrombosis. This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.
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