Journal
ANNUAL REVIEW OF BIOPHYSICS, VOL 42
Volume 42, Issue -, Pages 337-359Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-083012-130358
Keywords
bacterial chemotaxis; gradient sensing; receptor clustering; signal amplification; adaptation; modeling
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Funding
- NIGMS NIH HHS [GM081747, R01 GM081747] Funding Source: Medline
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We review the recent developments in understanding the bacterial chemotaxis signaling pathway by using quantitative modeling methods. The models developed are based on structural information of the signaling complex and the dynamics of the underlying biochemical network. We focus on two important functions of the bacterial chemotaxis signaling pathway: signal amplification and adaptation. We describe in detail the structure and the dynamics of the mathematical models and how they compare with existing experiments, emphasizing the predictability of the models. Finally, we outline future directions for developing the modeling approach to better understand the bacterial chemosensory system.
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