Journal
ANNUAL REVIEW OF BIOPHYSICS, VOL 41
Volume 41, Issue -, Pages 543-556Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-042910-155238
Keywords
cytoskeleton; signal transduction; spatial mutation
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [U54 CA143836] Funding Source: Medline
- NEI NIH HHS [PN2EY016586, PN2 EY016586] Funding Source: Medline
- NIAID NIH HHS [R37AI43542, R37 AI043542] Funding Source: Medline
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Signaling processes between various immune cells involve large-scale spatial reorganization of receptors and signaling molecules within the cell-cell junction. These structures, now collectively referred to as immune synapses, interleave physical and mechanical processes with the cascades of chemical reactions that constitute signal transduction systems. Molecular level clustering, spatial exclusion, and long-range directed transport are all emerging as key regulatory mechanisms. The study of these processes is drawing researchers from physical sciences to join the effort and represents a rapidly growing branch of biophysical chemistry. Recent advances in physical and quantitative analyses of signaling within the immune synapses are reviewed here.
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