Journal
ANNUAL REVIEW OF BIOPHYSICS, VOL 40
Volume 40, Issue -, Pages 63-80Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-biophys-042910-155227
Keywords
Escherichia coli; bacteriophage lambda; lysis/lysogeny; gene expression; physics of living cells; systems biology
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM082837] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM082837, R01GM082837] Funding Source: Medline
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The life cycle of bacteriophage lambda serves as a simplified paradigm for cell-fate decisions. The ongoing quantitative, high-resolution experimental investigation of this life cycle has produced some important insights in recent years. These insights have to do with the way cells choose among alternative fates, how they maintain long-term memory of their gene-expression state, and how they switch from one stable state to another. The recent studies have highlighted the role of spatiotemporal effects in cellular processes and the importance of distinguishing chemical stochasticity from possible hidden variables in cellular decision making.
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