Journal
ANNUAL REVIEW OF BIOPHYSICS, VOL 40
Volume 40, Issue -, Pages 243-266Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.biophys.093008.131331
Keywords
cation pumps; lipid flippases; structure; regulation
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P-type ATPases form a large superfamily of cation and lipid pumps. They are remarkably simple with only a single catalytic subunit and carry out large domain motions during transport. The atomic structure of P-type ATPases in different conformations, together with ample mutagenesis evidence, has provided detailed insights into the pumping mechanism by these biological nanomachines. Phylogenetically, P-type ATPases are divided into five subfamilies, P1-P5. These subfamilies differ with respect to transported ligands and the way they are regulated.
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